obtained some results for palladium catalysis

Group Research 05122017

I have made substrates for the development of intermolecular amino palladation reaction with phenol nucleophiles. initially, substrate synthesis was quite difficult with relatively low yields around 20 percent for the wittig olefination and 50 percent for cross metathesis. Through some optimization, the wittig reaction was raise to approximately 40 percent. Substrate development is pretty much completed. However, the palladium reactions encountered various difficuilty in ligand selection. RuPhos by far is the best ligand for the reaction. Temeperature was observed to make a impact on reactivity.

William N

Organic chemistry Researcher

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